Introduction

In-Vitro Fertilization or IVF is a technique of Assisted Reproduction developed to assist infertile couples in achieving pregnancy. During the course of an IVF program, the gametes, i.e. the sperm and the oocyte are retrieved from the male and female partner respectively and made to fuse artificially outside the body under laboratory conditions. This fusion of gametes then forms embryos which need to be cultured, a critical phase wherein the embryos develop, after which they can be transferred into the uterus of the patient.

Embryo culturing requires incubators which maintain a suitable and safe environment for the growth and development of these embryos. It is crucial that the incubator maintain accurate gas and temperature parameters A timelapse incubator enables one to keep track of the development of the embryos in real-time without having to remove them from their culturing environment. This not only ensures enhanced safety for the embryos but also allows for ease of traceability.

The MIRI® TL is a next-generation solution with highest standards for embryo safety, offering clinicians and embryologists peace of mind. Time-lapse monitoring enables an objective and reliable embryo scoring and the independent chambers of the incubator not only provide precise regulation of gas and temperature but also feature quick recovery times, ensuring a stress-free environment for the embryos.

Time-Lapse Incubation and its Significance

Time-lapse incubation in IVF refers to monitoring and incubation of embryos under a controlled environment with the use of an integrated camera or imaging system. Traditional incubation requires embryos to be removed from the incubator for assessment, whereas with time-lapse technology, it is possible to study the morphokinetic data of the embryo development from the safety of the incubator.

Embryo assessment using time-lapse data helps with several challenges of embryo culturing like fluctuations in temperature, pH and gas concentration, contamination of the culture dish due to repeated handling and subjective embryo assessment. Time-lapse incubation not only reduces the stress from external environment to the embryos, but it also allows one to make well-informed decisions leading to accurate assessment and higher implantation and pregnancy rates.

Why MIRI® TL Stands Out

  • Independent Incubation Chambers

    MIRI® TL features six or twelve chambers of incubation, each of which are independent from the other and dedicated to a single patient. This avoids cross-contamination between two chambers and allows for uninterrupted incubation. Each chamber has a glass lid which can be written upon with marker pens for ease of traceability.

  • Zero Cross-Contamination

    The chambers of the MIRI® TL provide isolated culture environments for each patient. Heated lids, in addition to the chamber itself, eliminate condensation and maintain optimized environment for embryo development.

  • Stable Conditions

    With MIRI® TL’s precise temperature and gas control and fast recovery times are assuring that the embryos will remain in stable culture conditions upon incubation. Individual incubation control enables optimal culture environments for each patient without disrupting other.

Key Benefits of MIRI® TL

  • Enhanced Embryo Development: Stressors from frequent handling are eliminated in continuous culture, which improves embryo quality. MIRI® TL maintains physiological parameters to facilitate IVF embryo safety.

  • Higher IVF Success Rates: Clinicians can choose between embryos using developmental kinetics rather than just the morphology when using time-lapse incubation. Continuous monitoring and a lower chance of contamination lead to higher rates of implantation and pregnancy.

  • Real-Time Monitoring: Embryologists can monitor developmental milestones with the MIRI® TL without taking the embryos out of the incubator. This keeps things steady and provides important information that helps with treatment scheduling and embryo selection.

Testimonials and Case Study

Medical Director, Dr. Eileen and her team at Co-Sy Fertility Clinic in Pampanga, Philippines are proud owners and users of a 12 chamber MIRI® TL. After integrating the MIRI® TL into their lab, the clinic reported improved consistency in embryo quality, simplified workflow, and enhanced patient satisfaction.

Full story: IVF Journey: Co-Sy Fertility Clinic - Pampanga, Philippines

Conclusion

Safe and optimized culturing of embryos is the key to increased implantation and pregnancy rates. MIRI® TL has redefined the standards for time-lapse incubation with its features such as the independent chamber design, precise environmental control and safety features, allowing higher success rates.

For clinics seeking to elevate outcomes and maintain a competitive edge, MIRI® TL is not just an option—it’s the gold standard.