Embryotools® Validates Esco Medical’s MIRI® M Multiroom IVF Incubator

Esco Medical is proud to announce that the MIRI® M Multiroom IVF Incubator has been independently evaluated and validated by Embryotools®, an internationally recognized laboratory operating under Good Laboratory Practice (GLP) standards.

The study confirms that the MIRI® M multiroom IVF Incubator provides stable, reliable, and equivalent embryo culture conditions compared to a standard benchtop incubator, while introducing unmatched flexibility and security for modern IVF laboratories.

Validated Under GLP Conditions

Embryotools® team conducted a comprehensive series of tests to evaluate the MIRI® M multiroom IVF incubators performance, including:

• Mouse embryo assays (cleavage rate, blastocyst formation, cell counts).
• Temperature and pH stability under normal and stress conditions.
• Resilience tests simulating power loss and environmental fluctuations.
• Humidity and osmolality monitoring for long-term culture integrity.

All procedures were performed under full GLP compliance with no deviations from approved protocols.

Equivalent Embryo Development Outcomes

Embryotools® cultured 438 embryos (378 in MIRI® M multiroom IVF incubator; 60 in control incubators) to compare developmental performance.

Results demonstrated no statistically significant differences between test and control groups:

• Cleavage Rate: 99.5% (MIRI® M) vs 100% (Control).
• Blastocyst Formation (Day 5/6): 95 – 96%.
• Good Quality Blastocysts: ~90%.
• Total Cell Counts: Comparable across all 18 chambers.

These results confirm that MIRI® M maintains the same level of embryo viability and morphology as the industry’s gold-standard systems.

Outstanding Thermal and Environmental Stability

Temperature stability and recovery are critical to embryo viability. Embryotools® findings revealed:

• Stable temperature (≤ 0.15°C fluctuation) under normal operation.
• Rapid temperature recovery (≈5 minutes) with deviations always within acceptable limits (±0.5 °C)* after door openings or handling.
• Resilience under stress: - Only 0.12°C average change during overnight A/C failure (+6°C ambient rise, reaching 30°C). - ~0.1°C deviation during a 30-minute power loss, full recovery within 1 hour.
• Stable pH range (7.2 – 7.4) maintained even after MIRI® M chamber lid was opened or relocated, indicating stable gas-phase control a minimal CO2 diffusion loss for at least 30 minutes.
• Consistent humidity (dry incubation system, 25 – 27% RH) and osmolality (260 – 285 mmol/kg) within the physiological range suitable for embryo culture across all chambers over long culture periods.

These findings demonstrate the MIRI® M multiroom IVF incubator robust design and environmental precision, even under challenging laboratory conditions.

Flexible, Modular, and Future-Ready

The MIRI® M multiroom IVF incubators innovative multiroom design features 18 independent chambers, each equipped with its own integrated battery. This allows each chamber to be undocked and handled individually – maintaining internal conditions for up to one hour without compromising culture stability.

Such flexibility enables embryologists to perform handling and transfer operations more efficiently, without disrupting ongoing cultures in other chambers.

Conclusion: Proven Performance and Reliability

Embryotools® evaluation demonstrated that the MIRI® M Multiroom IVF Incubator offers:

• Validated performance equivalent to benchmark systems.
• Stable environmental control under all tested conditions.
• Enhanced workflow flexibility through modular operation.
• Reliable culture protection even during power or A/C failures.

The MIRI® M represents a future-ready platform that combines scientific precision with operational freedom – a true evolution in IVF culture technology.

Empower every embryo with proven stability and innovation. [Discover the MIRI® M Today]